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Cancer is one of the leading causes of mortality in the world. Research has shown how black garlic, thanks to its antioxidant and anti-inflammatory properties<\/strong>, can act effectively in cancer prevention<\/strong>. Its bioactive compounds, such as S-allylcysteine (SAC)<\/strong> and S-allylmercaptocysteine (SAMC)<\/strong>, are the focus of numerous scientific studies. <\/p>\n Oxidative stress, caused by an excess of free radicals<\/strong>, damages DNA and promotes mutations that can lead to the development of tumors. Black garlic helps neutralize free radicals<\/strong>, protecting cells from damage and reducing the risk of malignant transformation [Ahmed & Wang, 2021][Park et al., 2014]<\/em>. <\/p>\n The SAC and SAMC compounds in black garlic directly affect cancer cells by:<\/p>\n Black garlic reduces the expression of MMP-2 and MMP-9 metalloproteinases<\/strong>, enzymes involved in the spread of cancer cells. In this way, it also acts on the prevention of metastasis<\/strong> [Ahmed & Wang, 2021]<\/em>. <\/p>\n Preclinical studies on colon, stomach and breast cancer<\/strong> cell lines show that black garlic extract<\/strong> reduces the proliferation of malignant cells and improves survival in animal models.<\/p>\n Thanks to these properties, black garlic is confirmed as a natural promise in cancer prevention<\/strong>, with potential applications also in the therapeutic field.<\/p>\n <\/p>\n \u2728 Learn more about the power of black garlic!<\/strong> To learn more about the benefits of fermented black garlic<\/strong>, visit the Health<\/a> section.<\/p>\n <\/p>\n A heartfelt thanks to Dr. Valentina Vecchi for her contribution to black garlic research, to Prof. Monica Borgatti for the academic guidance and to the University of Ferrara for its constant commitment to scientific research.<\/em><\/p>\n <\/p>\n SOURCES<\/span><\/p>\n Col\u00edn-Gonz\u00e1lez, A. L., Santana, R. A., Silva-Islas, C. A., Ch\u00e1nez-C\u00e1rdenas, M. E., Santamar\u00eda, A., & Maldonado, P. D. (2012). The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection. Oxidative Medicine and Cellular Longevity<\/em>, 2012<\/em>(1), 907162.<\/span> https:\/\/doi.org\/10.1155\/2012\/907162<\/span><\/a><\/p>\n Dai, F., Chen, W.-F., & Zhou, B. (2008). Antioxidant synergism of green tea polyphenols with alpha-tocopherol and L-ascorbic acid in SDS micelles. Biochimie<\/em>, 90<\/em>(10), 1499\u20131505. https:\/\/doi.org\/10.1016\/j.biochi.2008.05.007<\/a><\/span><\/p>\n Lee, Y.-M., Gweon, O.-C., Seo, Y.-J., Im, J., Kang, M.-J., Kim, M.-J., & Kim, J.-I. (2009). Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus. Nutrition Research and Practice<\/em>, 3<\/em>(2), 156. https:\/\/doi.org\/10.4162\/nrp.2009.3.2.156<\/a><\/span><\/p>\n Pedraza-Chaverr\u00ed, J., Barrera, D., Maldonado, P. D., Chirino, Y. I., Mac\u00edas-Ruvalcaba, N. A., Medina-Campos, O. N., Castro, L., Salcedo, M. I., & Hern\u00e1ndez-Pando, R. (2004). S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo. BMC Clinical Pharmacology<\/em>, 4<\/em>(1), 5. https:\/\/doi.org\/10.1186\/1472-6904-4-5<\/a> <\/span><\/p>\n Qiu, Z., Zheng, Z., Zhang, B., Sun-Waterhouse, D., & Qiao, X. (2020). Formation, nutritional value, and enhancement of characteristic components in black garlic: A review for maximizing the goodness to humans. Comprehensive Reviews in Food Science and Food Safety<\/em>, 19<\/em>(2), 801\u2013 834. https:\/\/doi.org\/10.1111\/1541-4337.12529<\/a> <\/span><\/p>\n Reddy, V. P. (2023). Oxidative Stress in Health and Disease. Biomedicines<\/em>, 11<\/em>(11), 2925. https:\/\/doi.org\/10.3390\/biomedicines11112925<\/a> <\/span><\/p>\n Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996). Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Biology & Medicine<\/em>, 20<\/em>(7), 933\u2013956. https:\/\/doi.org\/10.1016\/0891-5849(95)02227-9<\/a> <\/span><\/p>\n Zhao, L., Chen, J., Su, J., Li, L., Hu, S., Li, B., Zhang, X., Xu, Z., & Chen, T. (2013). In vitro antioxidant and antiproliferative activities of 5-hydroxymethylfurfural. Journal of Agricultural and Food Chemistry<\/em>, 61<\/em>(44), 10604\u201310611. https:\/\/doi.org\/10.1021\/jf403098y<\/a> <\/span><\/p>\n","protected":false},"excerpt":{"rendered":" Black Garlic and Cancer Prevention: A Promise from Nature Cancer is one of the leading causes of mortality in the world. Research has shown how black garlic, thanks to its antioxidant and anti-inflammatory properties, can act effectively in cancer prevention. Its bioactive compounds, such as S-allylcysteine (SAC) and S-allylmercaptocysteine (SAMC), are the focus of numerous […]<\/p>\n","protected":false},"author":2,"featured_media":8483,"template":"","categoria_salute":[182],"class_list":["post-8482","salute","type-salute","status-publish","has-post-thumbnail","hentry","categoria_salute-superfood"],"_links":{"self":[{"href":"https:\/\/www.nerofermento.it\/en\/wp-json\/wp\/v2\/salute\/8482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nerofermento.it\/en\/wp-json\/wp\/v2\/salute"}],"about":[{"href":"https:\/\/www.nerofermento.it\/en\/wp-json\/wp\/v2\/types\/salute"}],"author":[{"embeddable":true,"href":"https:\/\/www.nerofermento.it\/en\/wp-json\/wp\/v2\/users\/2"}],"version-history":[{"count":1,"href":"https:\/\/www.nerofermento.it\/en\/wp-json\/wp\/v2\/salute\/8482\/revisions"}],"predecessor-version":[{"id":9710,"href":"https:\/\/www.nerofermento.it\/en\/wp-json\/wp\/v2\/salute\/8482\/revisions\/9710"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nerofermento.it\/en\/wp-json\/wp\/v2\/media\/8483"}],"wp:attachment":[{"href":"https:\/\/www.nerofermento.it\/en\/wp-json\/wp\/v2\/media?parent=8482"}],"wp:term":[{"taxonomy":"categoria_salute","embeddable":true,"href":"https:\/\/www.nerofermento.it\/en\/wp-json\/wp\/v2\/categoria_salute?post=8482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Oxidative stress and cancer<\/h3>\n
Direct mechanisms: Apoptosis and proliferation blocking<\/h3>\n
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Indirect mechanisms: Inhibition of metastasis<\/h3>\n
Scientific evidence<\/h3>\n
\n Also read our article on black garlic and inflammation<\/a> or visit our official shop<\/a> to discover all its benefits.<\/p>\n<\/div>\n